Bone Abstracts

Background: Osteolytic lesions can be the presenting manifestation of various medical conditions, including bone tumors (benign and malignant) and infectious and endocrine diseases.Presenting problem: A 19-year-old Bedouin male from a consanguineous family was referred to our medical center for orthopedic consultation due to a pathological fracture and a cystic lesion in his right ulna. A skeletal survey revealed another cystic lesion in the left tibia. ...

Objective: Burosumab, a recombinant human monoclonal antibody that inhibits FGF23, was approved by the FDA in April, 2018 for the treatment of X-linked hypophosphatemia (XLH) in children and adults. XLH pediatric patients are typically affected with lower extremity deformities, short stature, bone pain, and limited physical activity. Burosumab is superior to conventional therapy in normalizing blood phosphate levels, thereby healing rickets, decreasing leg bowing, and reducing...

Background: X-linked hypophosphatemic rickets (XLH) is characterized by hypophosphatemia, bone deformities, and growth retardation. Conventional treatment of XLH with oral phosphate supplementation and high doses of vitamin D fails to normalize linear growth and adult stature remains disproportionately short. Few studies report on the use of recombinant human growth hormone (rhGH) therapy in pre-pubertal children with XLH.Presenting problem: Two brothers...